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. 2018 May 20;47:655-673.
doi: 10.1146/annurev-biophys-060414-034107.

The Physics of the Metaphase Spindle


The Physics of the Metaphase Spindle

David Oriola et al. Annu Rev Biophys. .


The assembly of the mitotic spindle and the subsequent segregation of sister chromatids are based on the self-organized action of microtubule filaments, motor proteins, and other microtubule-associated proteins, which constitute the fundamental force-generating elements in the system. Many of the components in the spindle have been identified, but until recently it remained unclear how their collective behaviors resulted in such a robust bipolar structure. Here, we review the current understanding of the physics of the metaphase spindle that is only now starting to emerge.

Keywords: active gel theory; dynein; kinesin; microtubules; mitotic spindle; molecular motors.

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