Cancer metabolism gets physical

Sci Transl Med. 2018 May 23;10(442):eaaq1011. doi: 10.1126/scitranslmed.aaq1011.


Patient-derived culture models enable assessment of drug sensitivity and can connect personalized genomics with therapeutic options. However, their clinical translation is constrained by limited fidelity. We outline how the physical microenvironment regulates cell metabolism and describe how engineered culture systems could enhance the predictive power for precision medicine.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Biophysical Phenomena*
  • Humans
  • Kinetics
  • Neoplasms / metabolism*
  • Precision Medicine
  • Translational Research, Biomedical
  • Tumor Microenvironment