Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Aug 10;361(6402):eaar6236.
doi: 10.1126/science.aar6236. Epub 2018 May 24.

Mapping the Dark Space of Chemical Reactions With Extended Nanomole Synthesis and MALDI-TOF MS

Affiliations

Mapping the Dark Space of Chemical Reactions With Extended Nanomole Synthesis and MALDI-TOF MS

Shishi Lin et al. Science. .

Abstract

Understanding the practical limitations of chemical reactions is critically important for efficiently planning the synthesis of compounds in pharmaceutical, agrochemical, and specialty chemical research and development. However, literature reports of the scope of new reactions are often cursory and biased toward successful results, severely limiting the ability to predict reaction outcomes for untested substrates. We herein illustrate strategies for carrying out large-scale surveys of chemical reactivity by using a material-sparing nanomole-scale automated synthesis platform with greatly expanded synthetic scope combined with ultrahigh-throughput matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOF MS).

Similar articles

See all similar articles

Cited by 8 articles

See all "Cited by" articles

Publication types

LinkOut - more resources

Feedback