Towards a Complete Map of the Human Long Non-Coding RNA Transcriptome

Nat Rev Genet. 2018 Sep;19(9):535-548. doi: 10.1038/s41576-018-0017-y.

Abstract

Gene maps, or annotations, enable us to navigate the functional landscape of our genome. They are a resource upon which virtually all studies depend, from single-gene to genome-wide scales and from basic molecular biology to medical genetics. Yet present-day annotations suffer from trade-offs between quality and size, with serious but often unappreciated consequences for downstream studies. This is particularly true for long non-coding RNAs (lncRNAs), which are poorly characterized compared to protein-coding genes. Long-read sequencing technologies promise to improve current annotations, paving the way towards a complete annotation of lncRNAs expressed throughout a human lifetime.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Chromosome Mapping*
  • Gene Expression Profiling*
  • Genome, Human*
  • Genome-Wide Association Study
  • Humans
  • RNA, Long Noncoding* / biosynthesis
  • RNA, Long Noncoding* / genetics
  • Transcriptome / physiology*

Substances

  • RNA, Long Noncoding