Cell Death and Development of Fibrotic Alterations in Lung Granuloma of BALB/c Mice during Chronic BCG-Induced Granulomatosis

L A Cherdantseva; O V Potapova; T V Sharkova; A M Anikina; A V Kovner; A V Troitskii; V A Shkurupy

doi:10.1007/s10517-018-4096-8

Cell Death and Development of Fibrotic Alterations in Lung Granuloma of BALB/c Mice during Chronic BCG-Induced Granulomatosis

Bull Exp Biol Med. 2018 May;165(1):48-51. doi: 10.1007/s10517-018-4096-8. Epub 2018 May 24.

Authors

L A Cherdantseva¹, O V Potapova², T V Sharkova², A M Anikina³, A V Kovner³, A V Troitskii³, V A Shkurupy⁴

Affiliations

¹ Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia. cherdanceff@yandex.ru.
² Optimum Medical Laboratory, Research-and-Educational Center, Sochi, Russia.
³ Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia.
⁴ Novosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk, Russia.

PMID: 29796808
DOI: 10.1007/s10517-018-4096-8

Abstract

Light microscopy, immunohistochemistry, and morphometric examinations established that cell death in lung granulomas of BCG-infected mice resulted mainly from activation of receptor-mediated apoptosis, which did not prevent the persistence of the causative agent in macrophages of the granulomas and promoted the formation of pronounced fibrosis in granulomas and pulmonary interstitium.

Keywords: BCG granulomatosis; apoptosis; fibrosis; immunohistochemistry; macrophages.

MeSH terms

Animals
Apoptosis / drug effects
Apoptosis / genetics
BCG Vaccine / adverse effects*
Fibroblasts / drug effects
Fibroblasts / metabolism
Granuloma / chemically induced*
Granuloma / pathology*
Immunohistochemistry
Macrophages / drug effects
Macrophages / metabolism
Male
Mice
Mice, Inbred BALB C

Substances

BCG Vaccine