New Fluorescent Reporter Systems for Evaluation of the Expression of E- and N-Cadherins

Bull Exp Biol Med. 2018 May;165(1):88-93. doi: 10.1007/s10517-018-4106-x. Epub 2018 May 24.


During metastatic growth, cells of solid tumors undergo phenotypical changes related to epithelial-mesenchymal transition. Epithelial-mesenchymal transition is regarded as a potential target for prospective antitumor drugs. Fluorescent reporter systems for evaluation of the expression of markers of epithelial and mesenchymal status (E- and N-cadherins) were created. The described approaches can be used for creation of analogous reporter systems.

Keywords: E-cadherin; N-cadherin; epithelial-mesenchymal transition; fluorescent reporters.

MeSH terms

  • Biomarkers, Tumor / genetics
  • Cadherins / genetics
  • Cadherins / metabolism*
  • Cell Line, Tumor
  • Epithelial-Mesenchymal Transition / drug effects
  • Epithelial-Mesenchymal Transition / genetics*
  • Gene Expression Regulation, Neoplastic / drug effects
  • Gene Expression Regulation, Neoplastic / genetics
  • Humans
  • Prospective Studies


  • Biomarkers, Tumor
  • Cadherins