Antitumor effect of 24R,25-dihydroxyvitamin D3

In Vivo. Mar-Apr 1988;2(2):129-32.

Abstract

24R,25(OH)2D3, one of the endogenous active metabolites of vitamin D3, showed suppressive effects on the proliferation of various tumor cells in vitro and a prolonging effect on the survival of P-388 bearing mice in vivo. Lewis lung carcinoma was found to cause hypercalcemia in tumor bearing mice. K-DR (24R,25(OH)2D3 (prepared by Kureha Chemical Ind.) significantly prolonged the survival of mice with Lewis lung carcinoma. K-DR also showed a suppressive effect on the growth of human osteosarcoma transplanted in nude mice.

MeSH terms

  • 24,25-Dihydroxyvitamin D 3 / pharmacology
  • 24,25-Dihydroxyvitamin D 3 / therapeutic use*
  • Animals
  • Antineoplastic Agents / therapeutic use*
  • Cell Line
  • Cell Survival / drug effects
  • Humans
  • Leukemia P388 / drug therapy*
  • Lung Neoplasms / drug therapy*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred Strains
  • Mice, Nude
  • Osteosarcoma / drug therapy*
  • Transplantation, Heterologous

Substances

  • Antineoplastic Agents
  • 24,25-Dihydroxyvitamin D 3