Nutritional Regulation of Intestinal Stem Cells

Annu Rev Nutr. 2018 Aug 21;38:273-301. doi: 10.1146/annurev-nutr-082117-051644. Epub 2018 May 23.


Dietary composition and calorie intake are major determinants of health and disease. Calorie restriction promotes metabolic changes that favor tissue regeneration and is arguably the most successful and best-conserved antiaging intervention. Obesity, in contrast, impairs tissue homeostasis and is a major risk factor for the development of diseases including cancer. Stem cells, the central mediators of tissue regeneration, integrate dietary and energy cues via nutrient-sensing pathways to maintain growth or respond to stress. We discuss emerging data on the effects of diet and nutrient-sensing pathways on intestinal stem cells, as well as their potential application in the development of regenerative and therapeutic interventions.

Keywords: calorie restriction; cancer; fasting; high-fat diet; intestinal stem cells.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging
  • Animals
  • Diet
  • Energy Intake
  • Humans
  • Intestines / cytology*
  • Nutritional Physiological Phenomena*
  • Stem Cells / physiology*