Association of Patient Sex With Chemotherapy-Related Toxic Effects: A Retrospective Analysis of the PETACC-3 Trial Conducted by the EORTC Gastrointestinal Group

JAMA Oncol. 2018 Jul 1;4(7):1003-1006. doi: 10.1001/jamaoncol.2018.1080.


This secondary analysis of the PETACC-3 trial examines the association of sex with incidence and severity of chemotherapy-related toxic effects in patients with stage II and III colorectal cancer treated with fluorouracil and leucovorin with or without irinotecan hydrochloride.

Publication types

  • Letter

MeSH terms

  • Aged
  • Drug Therapy / methods*
  • Drug-Related Side Effects and Adverse Reactions / epidemiology*
  • Female
  • Gastrointestinal Neoplasms / complications*
  • Gastrointestinal Neoplasms / drug therapy*
  • Gastrointestinal Neoplasms / pathology
  • Gender Identity*
  • Humans
  • Male
  • Middle Aged
  • Retrospective Studies