Oral Lichen Planus: an Overview of Potential Risk Factors, Biomarkers and Treatments

Asian Pac J Cancer Prev. 2018 May 26;19(5):1161-1167. doi: 10.22034/APJCP.2018.19.5.1161.


Oral lichen planus (OLP) is an immune-related disorder with unknown exact etiology but established prevalence in females. There are six clinical forms of OLP, ranging from asymptomatic white keratotic lesions to painful erosions and ulcerations. The aim of the present report is to overview pathologic and therapeutic aspects. Peroxidation products, antioxidants, cortisol, and immunoglobulins are potential biomarkers to predict OLP occurrence. The risk of OLP development in patients with hepatitis B and C infection is 2-fold greater than in healthy individuals, while there is no significant relation with diabetes mellitus. Corticosteroids are common drugs to treat OLP and their combination with other agents can be most effective. Folic acid and variants of vitamin B are also potential treatments since they target hematological abnormalities.

Keywords: Lichen Planus; oral; diagnosis; hepatitis; therapeutics; vitamins.

Publication types

  • Review

MeSH terms

  • Animals
  • Biomarkers / analysis*
  • Humans
  • Lichen Planus, Oral / diagnosis
  • Lichen Planus, Oral / etiology*
  • Lichen Planus, Oral / therapy*
  • Risk Factors


  • Biomarkers