New compounds inhibiting lipid accumulation from the stems of Sabia parviflora

Donghui Fan; Qi Wang; Yuwei Wang; Zhifeng Li; Lingling Pan; Shilin Yang; Yulin Feng

doi:10.1016/j.fitote.2018.05.021

New compounds inhibiting lipid accumulation from the stems of Sabia parviflora

Fitoterapia. 2018 Jul:128:218-223. doi: 10.1016/j.fitote.2018.05.021. Epub 2018 May 23.

Authors

Donghui Fan¹, Qi Wang¹, Yuwei Wang², Zhifeng Li³, Lingling Pan¹, Shilin Yang⁴, Yulin Feng⁵

Affiliations

¹ National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herb Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, PR China.
² Heilongjiang Provincial Hospital, Harbin 150000, PR China.
³ National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herb Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, PR China. Electronic address: lizhifeng1976@hotmail.com.
⁴ National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herb Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, PR China; State Key Laboratory of Innovative Drug and Efficient Energy-Saving Pharmaceutical Equipment, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, PR China.
⁵ State Key Laboratory of Innovative Drug and Efficient Energy-Saving Pharmaceutical Equipment, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, PR China. Electronic address: fengyulin2003@126.com.

PMID: 29802872
DOI: 10.1016/j.fitote.2018.05.021

Abstract

Four new compounds, sabianin A (1), sabianin B (2), sabianin C, (3) and sabianin D (4) together with seven known compounds (5-11) were isolated from the stems of Sabia parviflora. The structures of these compounds were elucidated by extensive spectroscopic analysis and by comparing their NMR data with those of related compounds. Their absolute configurations were determined by comparing the calculated and experimental electronic circular dichroism spectra. The lipid-lowering effect of all the compounds was evaluated using a cell model of steatosis induced by oleic acid and palmitic acid. Compounds 3, 6, and 10 showed statistically significant lipid-lowering effect.

Keywords: Lipid-lowering effect; Sabia parviflora; Sabiaceae; Sabianins A–D.

MeSH terms

Cell Line
Hepatocytes / drug effects*
Humans
Hypolipidemic Agents / chemistry*
Hypolipidemic Agents / isolation & purification*
Molecular Structure
Plant Stems / chemistry*
Tracheophyta / chemistry*

Substances

Hypolipidemic Agents