[Focus on clinical and pathological management of conjunctival melanocytic tumors]

Ann Pathol. 2018 Jun;38(3):153-163. doi: 10.1016/j.annpat.2018.03.006. Epub 2018 May 24.
[Article in French]

Abstract

Conjunctival-pigmented tumors are rare, but they are one of the most commonly encountered by the pathologist working with the department of ophthalmology. Nevus and melanoma can be encountered and have some histological difference compared to their cutaneous counterpart. Primary acquired melanosis (PAM) is a conjunctival specific entity. This clinical term includes several histological lesions ranging from benignity to melanoma precursor lesion. Histologic examination determines the therapy and the risk of progression to melanoma. We present here a histopathological, clinical and therapeutic synthesis of conjunctival-pigmented lesions, emphasizing the importance of a good understanding between clinicians and pathologists.

Keywords: Anatomie-pathologie; Clinique; Conjonctive; Conjunctive; Management; Melanoma; Melanosis; Mélanome; Mélanose; Nevus; Nævus; Pathology.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / adverse effects
  • Antineoplastic Agents / therapeutic use
  • Biomarkers, Tumor
  • Carcinoma in Situ / pathology
  • Carcinoma in Situ / surgery
  • Carcinoma in Situ / therapy
  • Combined Modality Therapy
  • Conjunctival Neoplasms / pathology*
  • Conjunctival Neoplasms / surgery
  • Conjunctival Neoplasms / therapy
  • Cryotherapy
  • Disease Management
  • Humans
  • Melanoma / pathology*
  • Melanoma / surgery
  • Melanoma / therapy
  • Melanosis / pathology
  • Melanosis / surgery
  • Melanosis / therapy
  • Neoplasm Staging
  • Nevus, Pigmented / pathology*
  • Nevus, Pigmented / surgery
  • Nevus, Pigmented / therapy
  • Physical Examination
  • Radiotherapy, Adjuvant / adverse effects

Substances

  • Antineoplastic Agents
  • Biomarkers, Tumor