Objective: To observe whether Ginkgo biloba extract (EGb761) can improve postoperative delirium in elderly patients. Methods: Eighty elderly patients undergoing tumor surgery at Zhejiang Cancer Hospital and complicated with postoperative delirium(POD) between June 2013 and July 2016 were randomly divided into treatment group (group A) and control group (group B) according to the random number table method. Patients in group A received ginkgo biloba extract (EGb761) drops oral treatment (3 times/d, 80 mg each time) in addition to oxygen inhalation and appeasement treatment. Patients in group B underwent routine oxygen inhalation and appeasement treatment. POD assessment was performed twice between the hours of 8: 00 am and 8: 00 pm daily after the diagnosis of POD. Observed indicators include sex ratio, age, body mass index (BMI), educated level, type of surgery, anesthesia method, duration of surgery, intraoperative mean arterial blood pressure, intraoperative blood loss, type of POD, visual analogue scale (VAS) scores when diagnosis of POD, the onset time of POD, initial RASS scores, duration of POD. Results: A total of 80 patients with POD were enrolled, 23 patients were excluded for did not cooperate with the tests of POD or refused to participate in the study. Finally, 57 elderly patients completed the study, 29 patients in the medication group (A group) and 28 patients in the control group (B group). There was no significant difference in sex ratio, age, BMI, education level, operation type, anesthesia method, operation duration, intraoperative mean arterial pressure, intraoperative blood loss, POD type and VAS score (all P>0.05). There was no significant difference between the two groups in POD onset time and initial RASS score (all P>0.05). The duration of POD in group A and group B was 16 (16)h and 48 (35) h respectively, the difference was statistically significant (U=161.500, P<0.001). Conclusion: Ginkgo biloba extract (EGb761) can shorten the course of POD in elderly patients.
目的： 观察银杏叶提取物(EGb761)改善老年患者术后谵妄(POD)的作用。 方法： 本研究为前瞻性研究。收集2013年6月至2016年7月期间在浙江省肿瘤医院行限期肿瘤手术、并且在术后发生POD的老年患者80例，按计算机随机数字表法随机分为银杏叶提取物(EGb761)用药组(A组)和对照组(B组)。A组患者除行常规吸氧和安抚治疗外，行银杏叶提取物滴剂口服治疗(3次/d，每次80 mg)。B组患者行常规吸氧和安抚治疗。POD确诊后，每天上午8点和下午8点之间行两次POD评估。观察指标包括2组患者的性别比例、年龄、体质指数(BMI)、学历水平、手术类型、麻醉方法、手术持续时间、术中平均动脉血压、术中出血量、POD类型、POD确诊时视觉模拟评分法(VAS)评分、POD发生时间和起始里士满躁动-镇静量表(RASS)评分、POD病程持续时间。 结果： 80例POD患者中，有23例不配合完成POD测试或拒绝参加研究而排除，最终57例老年患者完成研究，用药组(A组)29例和对照组(B组)28例。两组患者性别比例、年龄、BMI、学历水平、手术类型、麻醉方法、手术持续时间、术中平均动脉血压、术中出血量、POD类型、POD确诊时VAS评分比较，差异均无统计学意义(均P>0.05)。两组患者POD发生的时间和起始RASS评分比较，差异均无统计学意义(均P>0.05)。A组和B组患者POD病程持续时间分别为16(16)、48(35)h，差异有统计学意义(U＝161.500，P<0.001)。 结论： 银杏叶提取物(EGb761)可以缩短老年患者POD的病程。.
Keywords: Aged; Delirium; Ginkgo biloba extract; Postoperative Period.