A high omega-3 fatty acid diet rapidly changes the lipid composition of cardiac tissue and results in cardioprotection

Can J Physiol Pharmacol. 2018 Sep;96(9):916-921. doi: 10.1139/cjpp-2018-0043. Epub 2018 May 28.


The present study was designed to ascertain the effects of 3 diets with different omega-3/6 fatty acid ratios on infarct size and the modifications that these diets induce in the lipid composition of cardiac tissue. Sprague-Dawley rats were fed omega-3/6 fatty acid diets with 1:1, 1:5, or 1:20 ratios for at least 10 days, followed by occlusion of the left anterior descending artery for 40 min and 24 h of reperfusion. Infarct size was significantly smaller in the 1:1 group than in the other groups. Significantly higher concentrations of the omega-3 fatty acids eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid were found in the 1:1 group than in the other groups. Omega-6 polyunsaturated fatty acid levels were similar between groups, although they were higher in the 1:5 and 1:20 groups than in the 1:1 group. Margaric acid concentrations were higher in the 1:1 group than in the other groups. Docosahexaenoic acid levels in cardiac tissue and infarct size were significantly correlated with no other significant links being apparent. The present study indicated that a 1:1 omega-3/6 fatty acid ratio protected against ischemia and was associated with increased omega-3 fatty acid composition of cardiac tissue.

Keywords: acide margarique; infarctus du myocarde; inflammation; lipides; lipids; margaric acid; myocardial infarction; omega-3; omega-6; oméga 3; oméga 6; reperfusion.

MeSH terms

  • Animals
  • Cardiotonic Agents / pharmacology*
  • Diet*
  • Fatty Acids, Omega-3 / pharmacology*
  • Hemodynamics / drug effects
  • Lipids / chemistry*
  • Myocardial Infarction / prevention & control
  • Myocardium / cytology
  • Myocardium / metabolism*
  • Organ Size / drug effects
  • Rats
  • Rats, Sprague-Dawley
  • Time Factors


  • Cardiotonic Agents
  • Fatty Acids, Omega-3
  • Lipids