Vascular extracellular vesicles in comorbidities of heart failure with preserved ejection fraction in men and women: The hidden players. A mini review

Aisha Gohar; Dominique P V de Kleijn; Arno W Hoes; Frans H Rutten; Denise Hilfiker-Kleiner; Péter Ferdinandy; Joost P G Sluijter; Hester M den Ruijter

doi:10.1016/j.vph.2018.05.006

Vascular extracellular vesicles in comorbidities of heart failure with preserved ejection fraction in men and women: The hidden players. A mini review

Vascul Pharmacol. 2018 Dec;111:1-6. doi: 10.1016/j.vph.2018.05.006. Epub 2018 May 26.

Authors

Aisha Gohar¹, Dominique P V de Kleijn², Arno W Hoes³, Frans H Rutten³, Denise Hilfiker-Kleiner⁴, Péter Ferdinandy⁵, Joost P G Sluijter⁶, Hester M den Ruijter⁷

Affiliations

¹ Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht University, the Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, the Netherlands.
² Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht University, the Netherlands; Experimental Vascular Surgery, University Medical Center, Utrecht University & Netherlands Heart Institute, Utrecht, the Netherlands; Deptartment of Surgery, National University Singapore, Singapore.
³ Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, the Netherlands.
⁴ Department of Cardiology and Angiology, Medical School Hannover, Hannover, Germany.
⁵ Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary; Pharmahungary Group, Szeged, Hungary.
⁶ Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht University, the Netherlands; Regenerative Medicine Center, University Medical Center Utrecht, Utrecht University, the Netherlands.
⁷ Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht University, the Netherlands. Electronic address: H.M.denRuijter-2@umcutrecht.nl.

PMID: 29807165
DOI: 10.1016/j.vph.2018.05.006

Abstract

Left ventricular diastolic dysfunction, the main feature of heart failure with preserved ejection fraction (HFpEF), is thought to be primarily caused by comorbidities affecting the endothelial function of the coronary microvasculature. Circulating extracellular vesicles, released by the endothelium have been postulated to reflect endothelial damage. Therefore, we reviewed the role of extracellular vesicles, in particularly endothelium microparticles, in these comorbidities, including obesity and hypertension, to identify if they may be potential markers of the endothelial dysfunction underlying left ventricular diastolic dysfunction and HFpEF.

Keywords: Comorbidities; Endothelial microparticles; HFpEF; LVD; Sex.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cell-Derived Microparticles / metabolism
Cell-Derived Microparticles / pathology*
Comorbidity
Endothelial Cells / metabolism
Endothelial Cells / pathology*
Female
Heart Failure / epidemiology
Heart Failure / metabolism
Heart Failure / pathology*
Heart Failure / physiopathology
Humans
Hypertension / epidemiology
Hypertension / metabolism
Hypertension / pathology
Hypertension / physiopathology
Male
Obesity / epidemiology
Obesity / metabolism
Obesity / pathology
Obesity / physiopathology
Prognosis
Risk Factors
Sex Factors
Stroke Volume*
Ventricular Dysfunction, Left / epidemiology
Ventricular Dysfunction, Left / metabolism
Ventricular Dysfunction, Left / pathology*
Ventricular Dysfunction, Left / physiopathology
Ventricular Function, Left*