Vascular extracellular vesicles in comorbidities of heart failure with preserved ejection fraction in men and women: The hidden players. A mini review

Vascul Pharmacol. 2018 Dec;111:1-6. doi: 10.1016/j.vph.2018.05.006. Epub 2018 May 26.

Abstract

Left ventricular diastolic dysfunction, the main feature of heart failure with preserved ejection fraction (HFpEF), is thought to be primarily caused by comorbidities affecting the endothelial function of the coronary microvasculature. Circulating extracellular vesicles, released by the endothelium have been postulated to reflect endothelial damage. Therefore, we reviewed the role of extracellular vesicles, in particularly endothelium microparticles, in these comorbidities, including obesity and hypertension, to identify if they may be potential markers of the endothelial dysfunction underlying left ventricular diastolic dysfunction and HFpEF.

Keywords: Comorbidities; Endothelial microparticles; HFpEF; LVD; Sex.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell-Derived Microparticles / metabolism
  • Cell-Derived Microparticles / pathology*
  • Comorbidity
  • Endothelial Cells / metabolism
  • Endothelial Cells / pathology*
  • Female
  • Heart Failure / epidemiology
  • Heart Failure / metabolism
  • Heart Failure / pathology*
  • Heart Failure / physiopathology
  • Humans
  • Hypertension / epidemiology
  • Hypertension / metabolism
  • Hypertension / pathology
  • Hypertension / physiopathology
  • Male
  • Obesity / epidemiology
  • Obesity / metabolism
  • Obesity / pathology
  • Obesity / physiopathology
  • Prognosis
  • Risk Factors
  • Sex Factors
  • Stroke Volume*
  • Ventricular Dysfunction, Left / epidemiology
  • Ventricular Dysfunction, Left / metabolism
  • Ventricular Dysfunction, Left / pathology*
  • Ventricular Dysfunction, Left / physiopathology
  • Ventricular Function, Left*