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, 15 (12), 1085-1087

Metabolic Signaling Functions of the Heme oxygenase/CO System in Metabolic Diseases

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Metabolic Signaling Functions of the Heme oxygenase/CO System in Metabolic Diseases

Hyo Jeong Kim et al. Cell Mol Immunol.

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Roles of CO in metabolic homeostasis. Mitochondrial ROS induced by CO activate the PERK-eIF2α-ATF4 pathway. CO-induced ATF4 attenuates metabolic abnormalities by promoting SESN2-mediated lipolysis via autophagy or FGF21-mediated thermogenesis via browning or REDD1-mediated anti-tumorigenesis via mTORC1 inhibition. mTORC1 mechanistic target of rapamycin complex 1

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