Status of non-HDL-cholesterol and LDL-cholesterol among subjects with and without metabolic syndrome

J Pak Med Assoc. 2018 Apr;68(4):554-558.


Objective: To to compare non-high-density lipoprotein and low-density lipoprotein cholesterol among subjects with or without metabolic syndrome, glycation status and nephropathic changes.

Methods: The comparative cross-sectional study was carried out from Dec 21, 2015, to Nov 15, 2016, at the department of pathology and medicine PNS HAFEEZ and department of chemical pathology and clinical endocrinology (AFIP), and comprised patients of either gender visiting the out-patient department for routine screening. They were evaluated for anthropometric indices, blood pressure and sampled for lipid profile, fasting plasma glucose, glycated haemoglobin, insulin, and urine albumin-to-creatinine ratio. Subjects were segregated based upon presence (Group1) or absence (Group2) of metabolic syndrome based upon criteria of National Cholesterol Education Programme and the International Diabetes Federation. Differences in high and low density lipoprotein cholesterols were calculated between the groups.

Results: Of the 229 subjects, 120(52.4%) were women and 109(47.6%) were men. Overall, there were 107(46.7%) subjects in Group 1, and 122(53.3%) in Group 2. Non-high-density lipoprotein cholesterol was significantly different between subjects with and without metabolic syndrome as per both the study criteria (p<0.05 each). .

Conclusions: Non-high-density lipoprotein cholesterol levels were higher in subjects with metabolic syndrome.

Keywords: Non-HDL-cholesterol, LDL-cholesterol, Glycated haemoglobin, Homeostasis Model Assessment for Insulin Resistance, HOMA-IR, Fasting plasma glucose, FPG, Urine albumin creatinine ratio, UACR..

MeSH terms

  • Adult
  • Albuminuria / urine
  • Blood Glucose / metabolism
  • Case-Control Studies
  • Cholesterol, LDL / blood*
  • Creatinine / urine
  • Female
  • Glycated Hemoglobin / metabolism
  • Humans
  • Insulin Resistance
  • Male
  • Metabolic Syndrome / blood*
  • Metabolic Syndrome / physiopathology
  • Middle Aged


  • Blood Glucose
  • Cholesterol, LDL
  • Glycated Hemoglobin A
  • hemoglobin A1c protein, human
  • Creatinine