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Comparative Study
. 2018 Jul;7(7):685-691.
doi: 10.2217/cer-2017-0081. Epub 2018 May 29.

Factors Influencing Dabigatran or Warfarin Medication Persistence in Patients With Nonvalvular Atrial Fibrillation

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Comparative Study

Factors Influencing Dabigatran or Warfarin Medication Persistence in Patients With Nonvalvular Atrial Fibrillation

Srinivas Annavarapu et al. J Comp Eff Res. .

Abstract

Factors influencing differences in persistence between dabigatran and warfarin in patients with nonvalvular atrial fibrillation (NVAF) remain unclear.

Aim: Compare differences in persistence between new dabigatran and warfarin users in patients newly diagnosed with NVAF, adjusting for sociodemographics, clinical characteristics, patient out-of-pocket cost and other covariates.

Methods: A retrospective matched-cohort study was conducted using a US claims database of Medicare and commercially insured patients with NVAF aged≥ 18 years. Persistence and monthly out-of-pocket costs for dabigatran or warfarin were calculated and adjusted for covariates using Cox proportional hazard models.

Results & conclusion: Unadjusted persistence was significantly lower among dabigatran users (n = 1025) compared with matched warfarin users (38 vs 46%). Adjusting for covariates rendered this difference insignificant (hazard ratio = 0.930).

Keywords: dabigatran; nonvalvular atrial fibrillation; out of pocket cost; persistence; warfarin.

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