Association of Hydrochlorothiazide Use and Risk of Malignant Melanoma

doi:10.1001/jamainternmed.2018.1652

Multicenter Study

. 2018 Aug 1;178(8):1120-1122.

doi: 10.1001/jamainternmed.2018.1652.

Association of Hydrochlorothiazide Use and Risk of Malignant Melanoma

Anton Pottegård¹, Sidsel Arnspang Pedersen^{1

2

3}, Sigrun Alba Johannesdottir Schmidt⁴, Lisbet Rosenkrantz Hölmich⁵, Søren Friis^{4

6

7}, David Gaist^{2

3}

Affiliations

¹ Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark.
² Department of Neurology, Odense University Hospital, Odense, Denmark.
³ Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
⁴ Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
⁵ Department of Plastic Surgery, Herlev Gentofte Hospital, Herlev, Denmark.
⁶ Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark.
⁷ Department of Public Health, University of Copenhagen, Denmark.

PMID: 29813157
PMCID: PMC6143099
DOI: 10.1001/jamainternmed.2018.1652

Multicenter Study

Association of Hydrochlorothiazide Use and Risk of Malignant Melanoma

Anton Pottegård et al. JAMA Intern Med. 2018.

. 2018 Aug 1;178(8):1120-1122.

doi: 10.1001/jamainternmed.2018.1652.

Authors

Anton Pottegård¹, Sidsel Arnspang Pedersen^{1

2

3}, Sigrun Alba Johannesdottir Schmidt⁴, Lisbet Rosenkrantz Hölmich⁵, Søren Friis^{4

6

7}, David Gaist^{2

3}

Affiliations

¹ Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark.
² Department of Neurology, Odense University Hospital, Odense, Denmark.
³ Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
⁴ Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
⁵ Department of Plastic Surgery, Herlev Gentofte Hospital, Herlev, Denmark.
⁶ Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark.
⁷ Department of Public Health, University of Copenhagen, Denmark.

PMID: 29813157
PMCID: PMC6143099
DOI: 10.1001/jamainternmed.2018.1652

Abstract

This case-control study assesses the association of hydrochlorothiazide with risk of malignant melanoma among Danish adults.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Gaist received honoraria from AstraZeneca (Sweden) for participation as a coinvestigator in a research project outside this work. Dr Pottegård has participated in research projects, unrelated to the present study, using grants provided by LEO Pharma (manufacturer of bendroflumethiazide) to the institution where he was employed.

Comment in

[Hydrochlorothiazide appears to increase risk of melanoma].
Schmutz JL. Schmutz JL. Ann Dermatol Venereol. 2018 Oct;145(10):643-644. doi: 10.1016/j.annder.2018.07.007. Epub 2018 Aug 10. Ann Dermatol Venereol. 2018. PMID: 30104018 French. No abstract available.
Hydrochlorothiazide and the Risk of Malignant Melanoma.
van den Born BH, Olde-Engberink R, Vogt L. van den Born BH, et al. JAMA Intern Med. 2018 Oct 1;178(10):1425. doi: 10.1001/jamainternmed.2018.4312. JAMA Intern Med. 2018. PMID: 30285130 No abstract available.
Hydrochlorothiazide and the Risk of Malignant Melanoma-Reply.
Pottegård A, Gaist D. Pottegård A, et al. JAMA Intern Med. 2018 Oct 1;178(10):1425-1426. doi: 10.1001/jamainternmed.2018.4315. JAMA Intern Med. 2018. PMID: 30285138 No abstract available.

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References

1. Pottegård A, Hallas J, Olesen M, et al. . Hydrochlorothiazide use is strongly associated with risk of lip cancer. J Intern Med. 2017;282(4):322-331. doi:10.1111/joim.12629 - DOI - PubMed
1. Arnspang S, Gaist D, Johannesdottir Schmidt SA, Hölmich LR, Friis S, Pottegård A. Hydrochlorothiazide use and risk of non-melanoma skin cancer: A nationwide case-control study from Denmark. J Am Acad Dermatol. 2018;78(4):673-581.e9. doi:10.1016/j.jaad.2017.11.042 - DOI - PubMed
1. Schmidt M, Pedersen L, Sørensen HT. The Danish Civil Registration System as a tool in epidemiology. Eur J Epidemiol. 2014;29(8):541-549. doi:10.1007/s10654-014-9930-3 - DOI - PubMed
1. Jensen AØ, Thomsen HF, Engebjerg MC, Olesen AB, Sørensen HT, Karagas MR. Use of photosensitising diuretics and risk of skin cancer: a population-based case-control study. Br J Cancer. 2008;99(9):1522-1528. doi:10.1038/sj.bjc.6604686 - DOI - PMC - PubMed
1. Schmidt SAJ, Schmidt M, Mehnert F, Lemeshow S, Sørensen HT. Use of antihypertensive drugs and risk of skin cancer. J Eur Acad Dermatol Venereol. 2015;29(8):1545-1554. doi:10.1111/jdv.12921 - DOI - PubMed

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[1] Pottegård A, Hallas J, Olesen M, et al. . Hydrochlorothiazide use is strongly associated with risk of lip cancer. J Intern Med. 2017;282(4):322-331. doi:10.1111/joim.12629 - DOI - PubMed

[2] Pottegård A, Hallas J, Olesen M, et al. . Hydrochlorothiazide use is strongly associated with risk of lip cancer. J Intern Med. 2017;282(4):322-331. doi:10.1111/joim.12629 - DOI - PubMed

[3] Arnspang S, Gaist D, Johannesdottir Schmidt SA, Hölmich LR, Friis S, Pottegård A. Hydrochlorothiazide use and risk of non-melanoma skin cancer: A nationwide case-control study from Denmark. J Am Acad Dermatol. 2018;78(4):673-581.e9. doi:10.1016/j.jaad.2017.11.042 - DOI - PubMed

[4] Arnspang S, Gaist D, Johannesdottir Schmidt SA, Hölmich LR, Friis S, Pottegård A. Hydrochlorothiazide use and risk of non-melanoma skin cancer: A nationwide case-control study from Denmark. J Am Acad Dermatol. 2018;78(4):673-581.e9. doi:10.1016/j.jaad.2017.11.042 - DOI - PubMed

[5] Schmidt M, Pedersen L, Sørensen HT. The Danish Civil Registration System as a tool in epidemiology. Eur J Epidemiol. 2014;29(8):541-549. doi:10.1007/s10654-014-9930-3 - DOI - PubMed

[6] Schmidt M, Pedersen L, Sørensen HT. The Danish Civil Registration System as a tool in epidemiology. Eur J Epidemiol. 2014;29(8):541-549. doi:10.1007/s10654-014-9930-3 - DOI - PubMed

[7] Jensen AØ, Thomsen HF, Engebjerg MC, Olesen AB, Sørensen HT, Karagas MR. Use of photosensitising diuretics and risk of skin cancer: a population-based case-control study. Br J Cancer. 2008;99(9):1522-1528. doi:10.1038/sj.bjc.6604686 - DOI - PMC - PubMed

[8] Jensen AØ, Thomsen HF, Engebjerg MC, Olesen AB, Sørensen HT, Karagas MR. Use of photosensitising diuretics and risk of skin cancer: a population-based case-control study. Br J Cancer. 2008;99(9):1522-1528. doi:10.1038/sj.bjc.6604686 - DOI - PMC - PubMed

[9] Schmidt SAJ, Schmidt M, Mehnert F, Lemeshow S, Sørensen HT. Use of antihypertensive drugs and risk of skin cancer. J Eur Acad Dermatol Venereol. 2015;29(8):1545-1554. doi:10.1111/jdv.12921 - DOI - PubMed

[10] Schmidt SAJ, Schmidt M, Mehnert F, Lemeshow S, Sørensen HT. Use of antihypertensive drugs and risk of skin cancer. J Eur Acad Dermatol Venereol. 2015;29(8):1545-1554. doi:10.1111/jdv.12921 - DOI - PubMed

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Association of Hydrochlorothiazide Use and Risk of Malignant Melanoma

Affiliations

Association of Hydrochlorothiazide Use and Risk of Malignant Melanoma

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