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Multicenter Study
. 2018 Aug 1;178(8):1120-1122.
doi: 10.1001/jamainternmed.2018.1652.

Association of Hydrochlorothiazide Use and Risk of Malignant Melanoma

Free PMC article
Multicenter Study

Association of Hydrochlorothiazide Use and Risk of Malignant Melanoma

Anton Pottegård et al. JAMA Intern Med. .
Free PMC article


This case-control study assesses the association of hydrochlorothiazide with risk of malignant melanoma among Danish adults.

Conflict of interest statement

Conflict of Interest Disclosures: Dr Gaist received honoraria from AstraZeneca (Sweden) for participation as a coinvestigator in a research project outside this work. Dr Pottegård has participated in research projects, unrelated to the present study, using grants provided by LEO Pharma (manufacturer of bendroflumethiazide) to the institution where he was employed.

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    1. Pottegård A, Hallas J, Olesen M, et al. Hydrochlorothiazide use is strongly associated with risk of lip cancer. J Intern Med. 2017;282(4):322-331. doi:10.1111/joim.12629 - DOI - PubMed
    1. Arnspang S, Gaist D, Johannesdottir Schmidt SA, Hölmich LR, Friis S, Pottegård A. Hydrochlorothiazide use and risk of non-melanoma skin cancer: A nationwide case-control study from Denmark. J Am Acad Dermatol. 2018;78(4):673-581.e9. doi:10.1016/j.jaad.2017.11.042 - DOI - PubMed
    1. Schmidt M, Pedersen L, Sørensen HT. The Danish Civil Registration System as a tool in epidemiology. Eur J Epidemiol. 2014;29(8):541-549. doi:10.1007/s10654-014-9930-3 - DOI - PubMed
    1. Jensen AØ, Thomsen HF, Engebjerg MC, Olesen AB, Sørensen HT, Karagas MR. Use of photosensitising diuretics and risk of skin cancer: a population-based case-control study. Br J Cancer. 2008;99(9):1522-1528. doi:10.1038/sj.bjc.6604686 - DOI - PMC - PubMed
    1. Schmidt SAJ, Schmidt M, Mehnert F, Lemeshow S, Sørensen HT. Use of antihypertensive drugs and risk of skin cancer. J Eur Acad Dermatol Venereol. 2015;29(8):1545-1554. doi:10.1111/jdv.12921 - DOI - PubMed

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