Inhibition of hamster sperm Na+, K+-ATPase activity by taurine and hypotaurine

Life Sci. 1985 Jan 21;36(3):271-5. doi: 10.1016/0024-3205(85)90069-4.


Taurine, hypotaurine and the structural analogue, beta-alanine, were tested for their effects on Na+, K+-ATPase activity of crude homogenates prepared from washed cauda epididymal hamster sperm. Preincubation with 0.1-10 mM taurine or hypotaurine inhibited Na+, K+-ATPase in a dose-dependent manner, while beta-alanine had an inhibitory effect only at 10 mM. The results of this study are the first evidence to demonstrate inhibition of Na+, K+-ATPase activity by taurine and hypotaurine and are discussed in relation to the ability of these compounds to sustain hamster sperm motility and fertility.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cricetinae
  • Male
  • Sodium-Potassium-Exchanging ATPase / antagonists & inhibitors*
  • Spermatozoa / drug effects
  • Spermatozoa / enzymology*
  • Taurine / analogs & derivatives*
  • Taurine / pharmacology*
  • beta-Alanine / pharmacology


  • beta-Alanine
  • Taurine
  • hypotaurine
  • Sodium-Potassium-Exchanging ATPase