Small noncleaved B cell Burkitt-like lymphoma with chromosome t(8;14) translocation and Epstein-Barr virus nuclear-associated antigen in a homosexual man with acquired immune deficiency syndrome

Am J Med. 1985 Jan;78(1):141-8. doi: 10.1016/0002-9343(85)90475-9.


This case report describes new manifestations of the acquired immune deficiency syndrome (AIDS) in a promiscuous homosexual man. Investigation of upper gastrointestinal bleeding in the patient lead to discovery of a high-grade, small, noncleaved cell (Burkitt-like) gastroduodenal lymphoma with visceral and extralymphatic extension. Specific phenotyping of the lymphoma revealed that it was a monoclonal B cell lymphoma of mu kappa isotype. An in vitro cell line was established that was Epstein-Barr virus nuclear-associated antigen-positive. The lymphoma cells displayed a t(8;14) translocation similar to endemic African Burkitt lymphoma. Epstein-Barr virus genomes were identified in the lymphoma and an axillary lymph node biopsy specimen by molecular hybridization. These data strongly suggest that Epstein-Barr virus actively infected this patient. However, he showed normal Epstein-Barr virus-specific serologic responses, indicating an immune defect against the virus.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acquired Immunodeficiency Syndrome / complications*
  • Acquired Immunodeficiency Syndrome / immunology
  • Adult
  • Burkitt Lymphoma / complications*
  • Burkitt Lymphoma / immunology
  • Burkitt Lymphoma / pathology
  • Chromosome Aberrations
  • Chromosome Disorders
  • Chromosomes, Human, 13-15
  • Chromosomes, Human, 6-12 and X
  • Genes, Viral
  • Herpesvirus 4, Human / genetics
  • Herpesvirus 4, Human / immunology
  • Homosexuality
  • Humans
  • Karyotyping
  • Male
  • Translocation, Genetic*