Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

Nature. 1985 Feb 28-Mar 6;313(6005):756-61. doi: 10.1038/313756a0.


We have deduced the entire 1,370-amino-acid sequence of the human insulin receptor precursor from a single complementary DNA clone. The precursor starts with a 27-amino-acid signal sequence, followed by the receptor alpha-subunit, a precursor processing enzyme cleavage site, then the beta-subunit containing a single 23-amino-acid transmembrane sequence. There are sequence homologies to human epidermal growth factor receptor and the members of the src family of oncogene products.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • DNA / genetics
  • ErbB Receptors
  • Genes
  • Humans
  • Membrane Proteins / genetics
  • Molecular Weight
  • Oncogenes*
  • Protein Conformation
  • Protein Kinases / genetics*
  • Protein-Tyrosine Kinases
  • RNA, Messenger / genetics
  • Receptor, Insulin* / genetics
  • Receptors, Cell Surface / genetics


  • Membrane Proteins
  • RNA, Messenger
  • Receptors, Cell Surface
  • DNA
  • Protein Kinases
  • ErbB Receptors
  • Protein-Tyrosine Kinases
  • Receptor, Insulin

Associated data

  • GENBANK/X02160