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Review
. 2018 May 29;22(1):139.
doi: 10.1186/s13054-018-2058-1.

The Role of Adrenaline in Cardiopulmonary Resuscitation

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Free PMC article
Review

The Role of Adrenaline in Cardiopulmonary Resuscitation

Christopher J R Gough et al. Crit Care. .
Free PMC article

Abstract

Adrenaline has been used in the treatment of cardiac arrest for many years. It increases the likelihood of return of spontaneous circulation (ROSC), but some studies have shown that it impairs cerebral microcirculatory flow. It is possible that better short-term survival comes at the cost of worse long-term outcomes. This narrative review summarises the rationale for using adrenaline, significant studies to date, and ongoing research.

Keywords: Adrenaline; Cardiac arrest; Cardiopulmonary resuscitation; Epinephrine; Outcome.

Conflict of interest statement

Competing interests

CJRG declares no competing interests. JPN is a co-investigator for the National Institute of Health Research (NIHR) funded PARAMEDIC-2 trial and is Editor-in-Chief of the journal Resuscitation.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Forrest plot comparing ROSC for those who did, and did not, receive adrenaline (epinephrine)
Fig. 2
Fig. 2
Forrest plot comparing favourable neurological outcome (CPC 1–2) for those who did, and did not, receive adrenaline (epinephrine)
Fig. 3
Fig. 3
Forrest plot comparing ROSC for those who received high-dose adrenaline (HDA) compared with standard dose adrenaline (SDA)
Fig. 4
Fig. 4
Forrest plot comparing survival to hospital discharge for those who received high-dose adrenaline (HDA) compared with standard dose adrenaline (SDA)

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