Development and evaluation of cationic amphiphilic antimicrobial 2,5-diketopiperazines

J Pept Sci. 2018 Jul;24(7):e3090. doi: 10.1002/psc.3090. Epub 2018 May 29.

Authors

Christophe Labrière¹, Nahid Kondori², Josefin Seth Caous³, Marc Boomgaren¹, Kerstin Sandholm⁴, Kristina N Ekdahl^{4

5}, Jørn H Hansen¹, Johan Svenson^{1

3}

Affiliations

¹ Department of Chemistry, UiT The Arctic University of Norway, Tromsø, Norway.
² Department of Infectious diseases, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
³ Department of Chemistry and Materials, RISE Research Institutes of Sweden, Borås, Sweden.
⁴ Linnaeus Centre for Biomaterials Chemistry, Linnaeus University, Kalmar, Sweden.
⁵ Department of Immunology, Genetics and Pathology, Rudbeck Laboratory C5:3, Uppsala University, Uppsala, Sweden.

PMID: 29845683
DOI: 10.1002/psc.3090

No abstract available

Keywords: 2,5-diketopiperazine; Candida krusei; MRSA; antifungal agents; antimicrobial; structure-activity relationship.

MeSH terms

Anti-Bacterial Agents / chemical synthesis
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology*
Antifungal Agents / chemical synthesis
Antifungal Agents / chemistry
Antifungal Agents / pharmacology*
Antimicrobial Cationic Peptides / chemical synthesis
Antimicrobial Cationic Peptides / chemistry
Antimicrobial Cationic Peptides / pharmacology*
Bacteria / drug effects*
Candida / drug effects*
Diketopiperazines / chemical synthesis
Diketopiperazines / chemistry
Diketopiperazines / pharmacology*
Humans
Microbial Sensitivity Tests

Substances

Anti-Bacterial Agents
Antifungal Agents
Antimicrobial Cationic Peptides
Diketopiperazines
2,5-dioxopiperazine