The gut microbiome primes a cerebroprotective immune response after stroke

J Cereb Blood Flow Metab. 2018 Aug;38(8):1293-1298. doi: 10.1177/0271678X18780130. Epub 2018 May 30.


Microbiome alterations have been shown to affect stroke outcome. However, to what extent the presence of a gut microbiome per se is affecting post-stroke neuroinflammation has not been tested. By comparing germfree mice with recolonized (Ex-GF) and conventional SPF mice, we were able to demonstrate that bacterial colonization reduces stroke volumes. Bacterial colonization increased cerebral expression of cytokines as well as microglia/macrophage cell counts in contrast to improved stroke outcome. Interestingly, the microbiome-mediated brain protection was absent in lymphocyte-deficient mice. These findings support the concept of lymphocyte-driven protective neuroinflammation after stroke under control of the microbiome.

Keywords: Stroke; T cells; germfree; microbiota; microglia; neuroinflammation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Gastrointestinal Microbiome*
  • Immunity
  • Inflammation / complications
  • Inflammation / immunology*
  • Inflammation / pathology
  • Mice
  • Neuroprotection*
  • Protective Factors
  • Stroke / complications
  • Stroke / immunology*
  • Stroke / pathology
  • T-Lymphocytes / immunology*