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Review
. 2018;51(7):e6783.
doi: 10.1590/1414-431x20176783. Epub 2018 May 28.

Comparison of Serum PCT and CRP Levels in Patients Infected by Different Pathogenic Microorganisms: A Systematic Review and Meta-Analysis

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Free PMC article
Review

Comparison of Serum PCT and CRP Levels in Patients Infected by Different Pathogenic Microorganisms: A Systematic Review and Meta-Analysis

Jun-Hua Tang et al. Braz J Med Biol Res. .
Free PMC article

Abstract

To avoid the abuse and misuse of antibiotics, procalcitonin (PCT) and C-reactive protein (CRP) have been used as new approaches to identify different types of infection. Multiple databases were adopted to search relevant studies, and the articles that satisfied the inclusion criteria were included. Meta-analyses were conducted with Review Manager 5.0, and to estimate the quality of each article, risk of bias was assessed. Eight articles satisfied the inclusion criteria. The concentrations of both PCT and CRP in patients with bacterial infection were higher than those with non-bacterial infection. Both PCT and CRP levels in patients with G- bacterial infection were higher than in those with G+ bacterial infection and fungus infection. In the G+ bacterial infection group, a higher concentration of CRP was observed compared with fungus infection group, while the difference of PCT between G+ bacterial infection and fungus infection was not significant. Our study suggested that both PCT and CRP are helpful to a certain extent in detecting pneumonia caused by different types of infection.

Figures

Figure 1.
Figure 1.. Flow diagram of the study selection process and the reasons for exclusion.
Figure 2.
Figure 2.. Quality assessment of the included studies. Green: low risk of bias; Blank: unclear risk of bias; Red: high risk of bias.
Figure 3.
Figure 3.. Forest plot for the concentration of procalcitonin (PCT) between A) bacterial infection and control group, B) G+ bacterial infection and control group, C) G− bacterial infection and control group, and D) fungus infection and control group.
Figure 4.
Figure 4.. Forest plot for the concentration of procalcitonin (PCT) between A) G+ bacterial infection and G− bacterial infection group, B) G+ bacterial infection and fungus infection group, and C) G− bacterial infection and fungus infection group.
Figure 5.
Figure 5.. Forest plot for the concentration of CRP between A) bacterial infection and control group, B) G+ bacterial infection and control group, C) G− bacterial infection and control group, and D) fungus infection and control group.
Figure 6.
Figure 6.. Forest plot for the concentration of CRP between A) G+ bacterial infection and G− bacterial infection group, B) G+ bacterial infection and fungus infection group, and C) G− bacterial infection and fungus infection group.

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