Uncoupling Protein 2 and Peroxisome Proliferator-Activated Receptor γ Gene Polymorphisms in Association with Diabetes Susceptibility in Chinese Han Population with Variant Glucose Tolerance

Meicen Zhou; Shuli He; Fan Ping; Wei Li; Lixin Zhu; Xiangli Cui; Linbo Feng; Xuefeng Zhao; Huabing Zhang; Yuxiu Li; Qi Sun

doi:10.1155/2018/4636783

Uncoupling Protein 2 and Peroxisome Proliferator-Activated Receptor γ Gene Polymorphisms in Association with Diabetes Susceptibility in Chinese Han Population with Variant Glucose Tolerance

Int J Endocrinol. 2018 Apr 5:2018:4636783. doi: 10.1155/2018/4636783. eCollection 2018.

Authors

Meicen Zhou^{1

2}, Shuli He³, Fan Ping¹, Wei Li¹, Lixin Zhu⁴, Xiangli Cui⁴, Linbo Feng⁵, Xuefeng Zhao⁵, Huabing Zhang¹, Yuxiu Li¹, Qi Sun¹

Affiliations

¹ Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Beijing 100730, China.
² Department of Endocrinology, Beijing Jishuitan Hospital, Beijing 100035, China.
³ Department of Nutrition, Peking Union Medical College Hospital, Beijing 100730, China.
⁴ Nankou Community Health Service Centers, Changping District, Beijing 102200, China.
⁵ Nankou Railway Hospital, Changping District, Beijing 102200, China.

Abstract

Objective: To investigate the association of polymorphisms in uncoupling protein 2 (UCP2) and peroxisome proliferator-activated receptor (PPARγ) with glucolipid metabolism in Chinese Han population.

Methods: Five hundred eighty-nine subjects were divided into normal glucose tolerance (NGT) group (n = 198) and abnormal glucose tolerance group (n = 358). HbA1c, blood lipid profile, plasma glucose, and insulin were determined. Insulin sensitivity (HOMA-IR and Matsuda index (ISI_M)) and insulin secretion indexes (HOMA-β, early and total phase disposition index) were evaluated. Eight potential functional SNPs in UCP2 and 7 in PPARγ were selected. SNPs were genotyped on Sequenom MassARRAY platform.

Results: The GG genotype of rs2920502 in PPARγ was associated with decreased risk of impaired glucose tolerance (G allele: OR: 0.818, 95%CI: 0.526-0.969, P = 0.042; GG: OR: 0.715, 95%CI: 0.527-0.97, P = 0.031). The TT genotype of rs3856806 in PPARγ was associated with increased risk of impaired glucose tolerance (T allele: OR: 1.46, 95%CI: 1.055-2.017, P = 0.022; TT: OR: 1.58, 95%CI: 1.104-2.761, P = 0.032). The GG genotype of rs2920502 in PPARγ had better blood glucose and increased insulin secretion and had lower HOMA-IR than GC/CC genotypes.

Conclusion: It probably could prevent insulin resistance in early stage by classifying the genotype of rs649446 and rs7109266 in UCP2. The GG genotype of rs2920502 in PPARγ had a decreased risk for diabetes. The TT genotype of rs3856806 in PPARγ had an increased risk for diabetes.