Water proton NMR detection of amide hydrolysis and diglycine dimerization

Chem Commun (Camb). 2018 Jun 21;54(51):7003-7006. doi: 10.1039/c8cc03935f.


The transverse relaxation rate of water protons R2(1H2O) is found to be sensitive to amide hydrolysis and diglycine dimerization. The results demonstrate the feasibility of using R2(1H2O) as a diagnostic tool to detect chemical changes in aqueous solutions. Potential applications include drug product formulation and inspection.