Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2018 Apr 16;2017:1110-1119.
eCollection 2017.

X Marks the Spot: Mapping Similarity Between Clinical Trial Cohorts and US Counties

Affiliations
Free PMC article
Comparative Study

X Marks the Spot: Mapping Similarity Between Clinical Trial Cohorts and US Counties

Matthew C Lenert et al. AMIA Annu Symp Proc. .
Free PMC article

Abstract

When patients and doctors collaborate to make healthcare decisions, they rely on clinical trial results to guide discussions. Trials are designed to recruit diverse participants. The question remains - how well do trial results apply to me or to people who live in our area? This study compared one complete clinical trial dataset (SPRINT) and one published study (ACCORD) to the Community Health Status Indicators dataset to assess the similarity of the trial populations to US county populations. Counties up to 495 miles to the closest SPRINT trial site and up to 712 miles to the closest ACCORD trial site had populations that were significantly more similar to the study cohort than counties farther away. The investigators detail a generalizable method for both assessing recruitment gaps in large multicenter trials and creating maps for clinicians to provide intuition on trial applicability in their area.

Figures

Figure 1.
Figure 1.
Example of Near/Far County Definition From Vanderbilt University Medical Center (VUMC) Trial Site
Figure 2.
Figure 2.
Applicability Map of SPRINT Trial to US Counties
Figure 3.
Figure 3.
Distribution of SPRINT Similarity Across U.S. Counties
Figure 4.
Figure 4.
Applicability Map of ACCORD Trial to US Counties
Figure 5.
Figure 5.
Distribution of ACCORD Similarity Across U.S. Counties
Figure 6.
Figure 6.
SPRINT Intervention Group Difference in Primary Outcome Rates Grouped by Site

Similar articles

See all similar articles

Publication types

LinkOut - more resources

Feedback