Thallium replaces potassium in activation of the (Na+,K+)-ATPase of rat liver plasma membranes

J Appl Toxicol. 1985 Feb;5(1):32-4. doi: 10.1002/jat.2550050106.

Abstract

The capacity of thallium to substitute for K+ in activation of (Na+,K+)-ATPase of liver plasma membranes was studied. Our results indicate that T1+ can replace K+ in the activation of the (Na+,K+)-ATPase of liver plasma membranes. In the presence of Na+, similar activation is obtained with T1+ concentrations only 1/10 of those of K+. In all other aspects, the (Na+,K+)- and (Na+,T1+)-ATPases were found to be identical.

MeSH terms

  • Animals
  • Cell Membrane / enzymology
  • Enzyme Activation / drug effects
  • Hydrogen-Ion Concentration
  • In Vitro Techniques
  • Liver / enzymology*
  • Magnesium / metabolism
  • Ouabain / pharmacology
  • Potassium / pharmacology*
  • Rats
  • Sodium-Potassium-Exchanging ATPase / metabolism*
  • Temperature
  • Thallium / pharmacology*

Substances

  • Ouabain
  • Thallium
  • Sodium-Potassium-Exchanging ATPase
  • Magnesium
  • Potassium