Vitamin D supplementation may improve symptoms in Meniere's disease

Med Hypotheses. 2018 Jul;116:44-46. doi: 10.1016/j.mehy.2018.04.019. Epub 2018 Apr 24.

Abstract

In the last 4 years the authors observed a trend that correcting vitamin D deficiency in newly diagnosed cases of Meniere's disease decreased the necessity of the ablative therapy with intratympanic gentamicin. According to their hypothesis, vitamin D supplementation may indeed have a beneficial effect in Meniere's disease if the symptoms are caused by a local postviral autoimmune reaction. Vitamin D has a strong immunomodulatory role, one of which is the regulation of the expression of pro-inflammatory mediators. The authors suggest further epidemiological studies to decide if there is a connection between vitamin D deficiency and Meniere's disease.

Keywords: Deficiency; Meniere’s disease; Vitamin D.

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Autoimmunity
  • Cytokines / metabolism
  • Dietary Supplements
  • Gentamicins / therapeutic use
  • Humans
  • Inflammation
  • Meniere Disease / complications*
  • Meniere Disease / therapy*
  • Models, Theoretical
  • Vertigo
  • Vitamin D / analogs & derivatives
  • Vitamin D / blood
  • Vitamin D / therapeutic use*
  • Vitamin D Deficiency / complications*
  • Vitamin D Deficiency / therapy*

Substances

  • Anti-Bacterial Agents
  • Cytokines
  • Gentamicins
  • Vitamin D
  • 25-hydroxyvitamin D