An allometric approach of tumor-angiogenesis

Oliver Szasz; Gyula Vincze; Gyula Peter Szigeti; Zoltan Benyo; Andras Szasz

doi:10.1016/j.mehy.2018.03.015

An allometric approach of tumor-angiogenesis

Med Hypotheses. 2018 Jul:116:74-78. doi: 10.1016/j.mehy.2018.03.015. Epub 2018 Apr 21.

Authors

Oliver Szasz¹, Gyula Vincze¹, Gyula Peter Szigeti², Zoltan Benyo², Andras Szasz³

Affiliations

¹ Department of Biotechnics, St. Istvan University, Páter Károly Street 1, Godollo 2100, Hungary.
² Institute of Clinical Experimental Research, Semmelweis University, Tuzolto Street, 37-47, 1446, Hungary.
³ Department of Biotechnics, St. Istvan University, Páter Károly Street 1, Godollo 2100, Hungary. Electronic address: biotech@gek.szie.hu.

PMID: 29857914
DOI: 10.1016/j.mehy.2018.03.015

Abstract

Angiogenesis is one of the main supporting factors of tumor-progression. It is a complex set of interactions together with hypoxia and inflammation, regulating tumor growth. The objective of this study is to examine the effect of angiogenesis with an allometric approach applied to angiogenesis and the regulating factors. The results show that allometry has the potential to describe this aspect, including the sigmoid-like transport function. There are particular conditions under which the complex control maximizes the relative tumor mass. Linear growth of malignancy diameter with an allometric approach was proven.

Keywords: Allometry; Hypoxia; Inflammation.

MeSH terms

Animals
Humans
Hypoxia
Inflammation
Linear Models
Neoplasms / blood supply*
Neoplasms / pathology*
Neovascularization, Pathologic*