Role of Human Leukocyte Antigens (HLA) in Autoimmune Diseases

Gergely Bodis; Victoria Toth; Andreas Schwarting

doi:10.1007/978-1-4939-8546-3_2

Role of Human Leukocyte Antigens (HLA) in Autoimmune Diseases

Methods Mol Biol. 2018:1802:11-29. doi: 10.1007/978-1-4939-8546-3_2.

Authors

Gergely Bodis^{1

2}, Victoria Toth^{1

2}, Andreas Schwarting^{3

4}

Affiliations

¹ Bioscientia Institut für Medizinische Diagnostik GmbH, Ingelheim, Germany.
² Acura Rheumatology Center Rhineland Palatine, Bad Kreuznach, Germany.
³ Acura Rheumatology Center Rhineland Palatine, Bad Kreuznach, Germany. schwarting@uni-mainz.de.
⁴ Division of Rheumatology and Clinical Immunology, Department of Internal Medicine I, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany. schwarting@uni-mainz.de.

PMID: 29858799
DOI: 10.1007/978-1-4939-8546-3_2

Abstract

The aim of this review is to provide a brief overview of the role and current clinical relevance of HLA-B27 in spondyloarthritis and HLA-B51 in Behcet's disease as well as HLA-DQ2/DQ8 in celiac disease and HLA-DRB1 in rheumatoid arthritis and to discuss possible future implications.

Keywords: Autoimmunity; Behcet’s disease; HLA-B27; HLA-B51; HLA-DQ2/DQ8m HLA-DRB1; Rheumatoid arthritis; Spondyloarthritis.

Publication types

Review

MeSH terms

Autoimmune Diseases / immunology*
Epitopes / metabolism
HLA Antigens / metabolism*
Histocompatibility Antigens Class II / metabolism
Humans

Substances

Epitopes
HLA Antigens
Histocompatibility Antigens Class II