Go with the Flow: Cerebrospinal Fluid Flow Regulates Neural Stem Cell Proliferation

Naoko Kaneko; Kazunobu Sawamoto

doi:10.1016/j.stem.2018.05.015

Go with the Flow: Cerebrospinal Fluid Flow Regulates Neural Stem Cell Proliferation

Cell Stem Cell. 2018 Jun 1;22(6):783-784. doi: 10.1016/j.stem.2018.05.015.

Authors

Naoko Kaneko¹, Kazunobu Sawamoto²

Affiliations

¹ Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467-8601, Japan.
² Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467-8601, Japan; Division of Neural Development and Regeneration, National Institute for Physiological Sciences, Okazaki, Aichi 444-8787, Japan. Electronic address: sawamoto@med.nagoya-cu.ac.jp.

PMID: 29859165
DOI: 10.1016/j.stem.2018.05.015

Abstract

Adult neural stem cells in the wall of brain ventricles make direct contact with cerebrospinal fluid. In this issue of Cell Stem Cell, Petrik et al. (2018) demonstrate that these neural stem cells sense the flow of cerebrospinal fluid through a transmembrane sodium channel, ENaC, which regulates their proliferation.

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MeSH terms

Adult
Adult Stem Cells*
Cell Proliferation
Cerebral Ventricles
Epithelial Sodium Channels
Humans
Neural Stem Cells*

Substances

Epithelial Sodium Channels