Interspecies chimeras

Curr Opin Genet Dev. 2018 Oct;52:36-41. doi: 10.1016/j.gde.2018.05.007. Epub 2018 May 30.


By probing early embryogenesis and regeneration, interspecies chimeras provide a unique platform for discovery and clinical use. Although efficient generation of human:animal chimeric embryos remains elusive, recent advancements attempt to overcome incompatibilities in xenogeneic development and transplantation.

Publication types

  • Review

MeSH terms

  • Animals
  • Chimera / genetics*
  • Chimera / growth & development
  • Embryonic Development / genetics*
  • Humans
  • Pluripotent Stem Cells*
  • Species Specificity