Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes

Nature. 1985 May 9-15;315(6015):115-22. doi: 10.1038/315115a0.


Following the transfer into fertilized mouse eggs of recombinant genes composed of the upstream region of the rat insulin II gene linked to sequences coding for the large-T antigen of simian virus 40, large-T antigen is detected exclusively in the beta-cells of the endocrine pancreas of transgenic mice. The alpha- and delta-cells normally found in the islets of Langerhans are rare and disordered. Well-vascularized beta-cell tumours arise in mice harbouring and inheriting these hybrid oncogenes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenoma, Islet Cell / genetics*
  • Adenoma, Islet Cell / pathology
  • Animals
  • Antigens, Polyomavirus Transforming
  • Antigens, Viral, Tumor / genetics*
  • Cell Communication
  • DNA, Recombinant
  • Gene Expression Regulation
  • Insulin / genetics*
  • Mice
  • Oncogenes*
  • Pancreatic Neoplasms / genetics*
  • Pancreatic Neoplasms / pathology
  • Pedigree
  • Phenotype
  • Simian virus 40 / genetics
  • Tissue Distribution
  • Viral Proteins / genetics*


  • Antigens, Polyomavirus Transforming
  • Antigens, Viral, Tumor
  • DNA, Recombinant
  • Insulin
  • Viral Proteins