RIT2: responsible and susceptible gene for neurological and psychiatric disorders

Mol Genet Genomics. 2018 Aug;293(4):785-792. doi: 10.1007/s00438-018-1451-4. Epub 2018 Jun 2.


RIT2 gene was recently introduced as a susceptibility gene in neurological disorders, a group of major problems in human society affecting millions of people worldwide. Several variants, including single nucleotide polymorphisms and CNVs, have been identified and studied in different populations. In this review, we have summarized the studies relevant to the RIT2 gene and its related disorders, including Parkinson's disease, schizophrenia, and autism. The protein product of RIT2 is a member of the Ras superfamily that plays important roles in many vital cellular functions, such as differentiation and survival. We have also investigated the protein network of the RIT2 protein and the diseases related to members of this network so as to obtain some clues for future studies by identifying the molecular pathophysiology of neurological disorders and revealing new possible disorders related to RIT2.

Keywords: Autism; Bipolar disorder; Neurodegenerative disorder; Neurological disorder; Parkinson’s disease; RIT2; Ras; Schizophrenia.

Publication types

  • Review

MeSH terms

  • Animals
  • Autistic Disorder / genetics*
  • Autistic Disorder / metabolism
  • Genetic Predisposition to Disease*
  • Humans
  • Monomeric GTP-Binding Proteins / genetics*
  • Monomeric GTP-Binding Proteins / metabolism
  • Parkinson Disease / genetics*
  • Parkinson Disease / metabolism
  • Polymorphism, Single Nucleotide*
  • Schizophrenia / genetics*
  • Schizophrenia / metabolism


  • Monomeric GTP-Binding Proteins
  • RiT2 protein, human