The initiation of tumor is a complex process with multi-factor participation, particularly the activation of oncogenes and/or inactivation of tumor suppressor genes. Long non-coding RNAs (lncRNAs) play important roles in tumorigenesis. Additionally, as a metabolic process in cells, autophagy also contributes greatly to differentiation, metastasis and chemoresistance of tumor cells, and has become a central topic in recent years. The understanding of connection between lncRNAs and autophagy as well as their mechanisms underlying tumorigenesis, can provide new ideas for the diagnosis and treatment of tumors.
肿瘤的发生是一个多因素参与的复杂过程，通常与癌基因的激活或抑癌基因的失活有关。长链非编码RNA(lncRNA)在肿瘤的形成过程中发挥了重要的生物学作用，而自噬作为细胞内的一种代谢过程，也在肿瘤细胞分化、转移及耐药等方面扮演了重要角色，成为近年来的研究热点。深入研究和了解lncRNA与自噬的关系以及具体作用机制，有助于揭示肿瘤发生、发展，为肿瘤的诊断和治疗提供新的思路。.
Keywords: Autophagy; Long non-coding RNA; Neoplasms.