Egg Protein-Derived Bioactive Peptides: Preparation, Efficacy, and Absorption

Adv Food Nutr Res. 2018:85:1-58. doi: 10.1016/bs.afnr.2018.02.001. Epub 2018 Mar 21.


The hen's egg is an important protein source of human diet. On average one large egg contains ~6g protein, which contributes to ~11% of daily protein intake. As a high-quality protein, egg proteins are well recognized as excellent sources of bioactive peptides. The objectives of this chapter are to introduce generation, bioactivities, and absorption of egg protein-derived bioactive peptides. Research on egg protein-derived bioactive peptides has been progressed during the past decades. Enzymatic hydrolysis is the major technique to prepare bioactive peptides from egg protein. Quantitative structure-activity relationships-aided in silico prediction is increasingly applied as a promising tool for efficient prediction of novel bioactive peptides. A number of bioactive peptides from egg proteins have been characterized for antioxidant, immunomodulatory, antihypertensive, antidiabetic, anticancer, and antimicrobial activities. Egg protein-derived peptides that can improve bone health have been reported as well. However, molecular mechanisms of many peptides are not fully understood. The stability and absorption routes, bioavailability, safety, and production of bioactive peptides await further investigation.

Keywords: Anticancer activity; Antidiabetic activity; Antihypertensive activity; Antimicrobial activity; Antioxidant activity; Bioactive peptides; Bioavailability; Egg protein; Immunomodulatory activity; Scale-up production.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Computer Simulation
  • Egg Proteins / chemistry*
  • Eggs / analysis*
  • Humans
  • Peptides / chemistry*
  • Peptides / pharmacology*
  • Structure-Activity Relationship


  • Egg Proteins
  • Peptides