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. 2018 May;13(5):817-818.
doi: 10.4103/1673-5374.232475.

Hyperbaric oxygen therapy as a new treatment approach for Alzheimer's disease

Ronit Shapira  1 , Shai Efrati  2 , Uri Ashery  3
Affiliations

Hyperbaric oxygen therapy as a new treatment approach for Alzheimer's disease

Ronit Shapira et al. Neural Regen Res. 2018 May.
No abstract available

PubMed Disclaimer

Conflict of interest statement

None declared

Figures

Figure 1
Figure 1
Hypoxia and hyperbaric oxygen therapy (HBOT) effect on neurons and microglia. Hypoxia (red), the lack of oxygen in the tissue, contributes to the accumulation of amyloid plaques, phosphorylation of tau and loss of synapses and neurons that ultimately leads to cognitive decline. HBOT (green) reduces hypoxia (elevates the partial pressure of oxygen (pO2)), amyloid burden and tau phosphorylation, decreases the total levels of GSK3β, and improves cognitive performance. Furthermore, HBOT induces a morphological change in microglia near plaques to a more ramified state, reduces the secretion of proinflammatory cytokines (interleukin (IL)-1β, tumor necrosis factor alpha (TNF-α)) and increases the secretion of antiinflammatory cytokines (IL-4, IL-10). GSK3β: Glycogen synthase kinase 3β.
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