Polyglucosan bodies in the sural nerve of a diabetic patient with polyneuropathy

Acta Neuropathol. 1985;66(1):83-6. doi: 10.1007/BF00698301.


In the sural nerve of a 62-year-old woman with impaired glucose tolerance test and polyneuropathy, many intra-axonal polyglucosan bodies were observed. Polyglucosan bodies have been described in spontaneously or alloxan-diabetic rats, but are not usually observed in human diabetic neuropathy. Since intra-axonal polyglucosan bodies can occur in the sural nerve in various diseases and in aging, they are considered as non-specific changes. Their presence is probably related to a primary axonal neuropathy.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Axons / ultrastructure
  • Biopsy
  • Diabetic Neuropathies / pathology*
  • Female
  • Glucans / metabolism*
  • Humans
  • Inclusion Bodies / ultrastructure*
  • Microscopy, Electron
  • Middle Aged
  • Muscular Atrophy / pathology
  • Myelin Sheath / ultrastructure
  • Spinal Nerves / pathology*
  • Sural Nerve / pathology*


  • Glucans