Circulating malondialdehyde concentrations in patients with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis

Biomark Med. 2018 Jul;12(7):771-781. doi: 10.2217/bmm-2017-0420. Epub 2018 Jun 5.


The aim of this meta-analysis was to review the available evidence regarding the blood concentrations of the oxidative stress marker malondialdehyde (MDA) in chronic obstructive pulmonary disease (COPD) patients in comparison to healthy individuals. 14 studies were included in the meta-analysis (from inception to October 2017) with a total of 817 COPD patients and 530 healthy controls. Pooled MDA concentrations were significantly higher in patients with COPD than controls (standardized mean differences = 2.39 μmol/l, 95% CI: 1.50-3.28 μmol/l; p < 0.001). Our meta-analysis showed that the blood concentrations of MDA are consistently higher in patients with COPD when compared with healthy controls, suggesting an important role of lipid peroxidation, and thus oxidative stress, in the pathogenesis of COPD.

Keywords: ATS; GOLD; SMD; TBARS; chronic obstructive pulmonary disease; lipid peroxidation; malondialdehyde; oxidative stress; plasma; serum.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't
  • Systematic Review

MeSH terms

  • Humans
  • Malondialdehyde / blood*
  • Pulmonary Disease, Chronic Obstructive / blood*
  • Pulmonary Disease, Chronic Obstructive / metabolism
  • Pulmonary Disease, Chronic Obstructive / pathology


  • Malondialdehyde