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Comparative Study
, 62 (8)

Evaluation of the Bactericidal Activity of Plazomicin and Comparators Against Multidrug-Resistant Enterobacteriaceae

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Comparative Study

Evaluation of the Bactericidal Activity of Plazomicin and Comparators Against Multidrug-Resistant Enterobacteriaceae

M Thwaites et al. Antimicrob Agents Chemother.

Abstract

The next-generation aminoglycoside plazomicin, in development for infections due to multidrug-resistant (MDR) Enterobacteriaceae, was evaluated alongside comparators for bactericidal activity in minimum bactericidal concentration (MBC) and time-kill (TK) assays against MDR Enterobacteriaceae isolates with characterized aminoglycoside and β-lactam resistance mechanisms. Overall, plazomicin and colistin were the most potent, with plazomicin demonstrating an MBC50/90 of 0.5/4 μg/ml and sustained 3-log10 kill against MDR Escherichia coli, Klebsiella pneumoniae, and Enterobacter spp.

Keywords: Enterobacteriaceae; bactericidal; bactericidal activity; multidrug resistance; plazomicin.

Figures

FIG 1
FIG 1
(a) Time-kill kinetics of plazomicin against E. coli. (b) Time-kill kinetics of plazomicin against K. pneumoniae. (c) Time-kill kinetics of plazomicin against Enterobacter spp. Black diamonds, growth control; gray X's, plazomicin at 2× MIC; circles, plazomicin at 4× MIC; triangles, plazomicin at 8× MIC; gray diamonds, plazomicin at 16× MIC. Upper horizontal dashed lines represent the 3-log10 CFU decrease from time zero (t0); lower dotted horizontal lines represent the limits of detection.

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