Research and clinical potential of receptor based radiopharmaceuticals

J Nucl Med. 1985 Jun;26(6):655-62.


Receptors are proteins that have specific binding affinity for substances that produce a physiological event in the body. Receptor-binding radiotracers are being used increasingly to study the function of receptors in health and disease. This review summarizes the proceedings of a symposium on research in the development of receptor-binding radiopharmaceuticals. The key phases in this research include: selection of the receptor system and ligand; synthesis of radiolabeled ligand; validation in animal models; and clinical application. Current research involves a variety of biological systems, such as butyrophenone neuroleptics for dopamine receptors and steroidal estrogens for the estrogen receptor. In the future, it is believed that receptor-binding radiopharmaceuticals will be useful, not only to validate receptor systems in vivo, but also to aid in the diagnosis and therapy of human diseases.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Binding Sites
  • Carbon Radioisotopes
  • Fluorine
  • Humans
  • Radioisotopes*
  • Radioligand Assay*
  • Receptors, Cell Surface / analysis*
  • Tissue Distribution
  • Tomography, Emission-Computed


  • Carbon Radioisotopes
  • Radioisotopes
  • Receptors, Cell Surface
  • Fluorine