Inflammatory Dietary Pattern, IL-17F Genetic Variant, and the Risk of Colorectal Cancer

Nutrients. 2018 Jun 5;10(6):724. doi: 10.3390/nu10060724.


A proinflammatory diet may increase the risk of colorectal cancer, but its role may differ according to individuals' genetic variants. We aimed to examine whether a specific dietary pattern reflecting inflammation was associated with a risk of colorectal cancer and whether IL-17F genetic variant altered this association. In a study of 695 colorectal cancer cases and 1846 controls, we derived a reduced rank regression dietary pattern using 32 food groups as predictors and the plasma C-reactive protein (CRP) concentration as the response. High CRP levels were associated with a high risk of colorectal cancer (OR (95% CI) = 3.58 (2.65⁻4.82) for the highest quartile vs. lowest quartile). After adjusting for potential confounding factors, high pattern scores were associated with a high risk of colorectal cancer (OR (95% CI) = 9.98 (6.81⁻14.62) for the highest quartile vs. lowest quartile). When stratified by the IL-17F rs763780 genotype, this association was stronger for individuals carrying the C allele (p for interaction = 0.034), particularly for individuals with rectal cancer (p for interaction = 0.011). In conclusion, a dietary pattern reflecting inflammation was significantly associated with colorectal cancer risk. Moreover, this association could be modified according to the IL-17F rs763780 genotype and anatomic site.

Keywords: C-reactive protein; IL-17F polymorphism; colorectal cancer; dietary pattern; inflammation.

MeSH terms

  • Aged
  • C-Reactive Protein / analysis
  • Case-Control Studies
  • Chi-Square Distribution
  • Colorectal Neoplasms / blood
  • Colorectal Neoplasms / epidemiology
  • Colorectal Neoplasms / genetics*
  • Colorectal Neoplasms / immunology
  • Diet / adverse effects*
  • Feeding Behavior*
  • Female
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Humans
  • Inflammation / blood
  • Inflammation / epidemiology
  • Inflammation / genetics*
  • Inflammation / immunology
  • Inflammation Mediators / blood
  • Interleukin-17 / genetics*
  • Linear Models
  • Logistic Models
  • Male
  • Middle Aged
  • Odds Ratio
  • Phenotype
  • Polymorphism, Single Nucleotide*
  • Republic of Korea / epidemiology
  • Risk Assessment
  • Risk Factors


  • IL17F protein, human
  • Inflammation Mediators
  • Interleukin-17
  • C-Reactive Protein