A haunted beast: Targeting STAT5B N642H in T-Cell Neoplasia

Mol Cell Oncol. 2018 Mar 28;5(3):e1435181. doi: 10.1080/23723556.2018.1435181. eCollection 2018.

Abstract

The somatic hot spot mutation STAT5BN642H was found in many T cell leukemia/lymphoma patients. We generated and analyzed a transgenic mouse model with hematopoietic STAT5BN642H expression that caused aggressive T-cell leukemia/lymphomas. Herein, we discuss the scientific merit of our model and its relevance for pre-clinical studies.

Keywords: Aurora kinase; JAK kinase; STAT5 N642H driver mutation; T-cell neoplasia.

Grant support

This work was supported by the by the Austrian Science Fund (FWF) under Grant SFB-F4707-B20 and SFB-F6105.