Aspergillus Sternomyelitis Developed from Chronic Pulmonary Aspergillosis as a Late Complication to Lobectomy for Lung Cancer

Intern Med. 2018 Oct 15;57(20):2991-2994. doi: 10.2169/internalmedicine.0334-17. Epub 2018 Jun 6.


Progressive fibrobullous changes in the residual lobes are sometimes observed after lobectomy. Aspergillus osteomyelitis is an uncommon infection that rarely occurs sternally. A 70-year-old man who had undergone lobectomy 12 years earlier was admitted to our hospital for chest pain. He was diagnosed with Aspergillus sternomyelitis based on sternal bone culture after an ultrasound-guided percutaneous needle biopsy. The fibrosis and right residual lung apex volume loss had gradually progressed over 12 years, and therefore, chronic pulmonary aspergillosis (CPA) with direct invasion sternal from the CPA was considered. Aspergillus sternomyelitis can develop from CPA as a late complication of lobectomy.

Keywords: Aspergillus sternomyelitis; chronic pulmonary aspergillosis; late complication; lobectomy.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anti-Bacterial Agents / therapeutic use
  • Humans
  • Lung Diseases, Fungal / complications*
  • Lung Diseases, Fungal / therapy*
  • Lung Neoplasms / complications*
  • Lung Neoplasms / pathology
  • Lung Neoplasms / surgery*
  • Male
  • Myelitis, Transverse / drug therapy*
  • Myelitis, Transverse / etiology
  • Myelitis, Transverse / surgery*
  • Pneumonectomy / adverse effects
  • Pulmonary Aspergillosis / diagnosis
  • Pulmonary Aspergillosis / drug therapy*
  • Pulmonary Aspergillosis / etiology
  • Pulmonary Aspergillosis / surgery*
  • Treatment Outcome
  • Voriconazole / therapeutic use


  • Anti-Bacterial Agents
  • Voriconazole