Legionella Pneumonia Complicated with Acquired Fanconi Syndrome

Intern Med. 2018 Oct 15;57(20):2975-2980. doi: 10.2169/internalmedicine.0942-18. Epub 2018 Jun 6.


Legionella pneumonia is occasionally accompanied by renal complications; however, the cause of this remains unknown. We herein report a 70-year-old Japanese man with Legionella pneumonia who presented with hyponatremia, hypophosphatemia, and hypouricemia. The levels of urinary β2-microglobulin and N-acetyl-β-D-glucosaminidase were remarkably high, indicating severe renal tubular damage. The presence of glycosuria and aminoaciduria as well as increased fractional excretion of uric acid and decreased tubular reabsorption of phosphate indicated that the patient's condition was complicated with Fanconi syndrome. After antimicrobial therapy, the electrolyte abnormalities and renal tubular damage were completely resolved.

Keywords: Fanconi syndrome; Legionella pneumonia; aminoaciduria; rhabdomyolysis.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anti-Bacterial Agents / therapeutic use*
  • Asian Continental Ancestry Group
  • Fanconi Syndrome / etiology*
  • Humans
  • Hyponatremia / complications*
  • Hypophosphatemia / complications*
  • Legionnaires' Disease / complications*
  • Legionnaires' Disease / drug therapy*
  • Male
  • Pneumonia / complications*
  • Treatment Outcome


  • Anti-Bacterial Agents