Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 28 (14), 2485-2489

1,2-Diphenoxiethane Salts as Potent Antiplasmodial Agents

Affiliations

1,2-Diphenoxiethane Salts as Potent Antiplasmodial Agents

Santiago Schiafino-Ortega et al. Bioorg Med Chem Lett.

Abstract

In this article we present a series of non-cytotoxic potent human choline kinase (CK) inhibitors that exhibit nanomolar antiplasmodial activity in vitro. The most active antiplasmodial compounds, 10a-b, bearing a pyridinium cationic head were inactive against CK, while compounds 10g and 10j with a quinolinium moiety exhibit moderate inhibition of both the parasite and the enzyme. The results point towards an additional mechanism of action unrelated to CK inhibition that remains to be established.

Keywords: Antiplasmodial agents; Non-cytotoxic; Plasmodium falciparum.

Similar articles

See all similar articles

Publication types

MeSH terms

Feedback