Deregulation of interleukin-2 receptor gene expression in HTLV-I-induced adult T-cell leukemia

Science. 1985 Jun 7;228(4704):1215-7. doi: 10.1126/science.2988127.


Infection of human T cells by human T-lymphotropic virus, type I (HTLV-I), a retrovirus, is uniformly associated with the constitutive expression of large numbers of cellular receptors for interleukin-2 (IL-2). Comparison with normal T cells shows that neither IL-2 receptor gene organization nor IL-2 receptor messenger RNA processing are altered in the leukemic cells. However, mitogenic stimuli activate IL-2 receptor gene expression in normal T cells, whereas these stimuli paradoxically inhibit IL-2 receptor gene transcription in HTLV-I-infected leukemic T cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Nucleus / physiology
  • Cells, Cultured
  • DNA / genetics
  • Deltaretrovirus
  • Humans
  • Leukemia / genetics*
  • Molecular Weight
  • Poly A / genetics
  • RNA, Messenger / genetics
  • Receptors, Immunologic / genetics*
  • Receptors, Interleukin-2
  • T-Lymphocytes / microbiology
  • T-Lymphocytes / physiology*
  • Transcription, Genetic


  • RNA, Messenger
  • Receptors, Immunologic
  • Receptors, Interleukin-2
  • Poly A
  • DNA